Raquel Maria Soengas
  Telefone:
  Extensão:
23522
  e-mail:
rsoengas@ua.pt
  Categoria:
Investigadora Auxiliar
  Departamento:
Química
  Gabinete:
15.2.14
  Grupo de investigação:
Química Orgânica
  Pesquisa no ISI web of knowledge:
Soengas RG
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Formação académica


2003: Doutoramento Europeu, Faculdade de Química, Universidade de Santiago de Compostela/Dyson Perrin Laboratory, University of Oxford sobre o tema “Novas estrategias de síntese de ?-, ?- e ?-aminoácidos polihidroxilados e compostos relacionados”.


2001: Mestrado em Química, Faculdade de Química, Universidade de Santiago de Compostela sobre o tema “Aplicación da reação de Henry à síntese de aminoácidos carbocíclicos”


1999: Mestrado em Química Orgánica, Faculdade de Química, Universidade de Santiago de Compostela sobre o tema “Estudos sobre a síntese de aminoácidos carbocíclicos”


1998: Licenciatura em Química, Faculdade de Química, Universidade de Santiago de Compostela

    


Percurso profissional

Atividade docente

2006-2010: Professora auxiliar, Faculdade de Ciências, Universidade de A Coruña.


1999-2002: Colaborador docente, Faculdade de Ciências (Lugo), Faculdade de Química Universidade de Santiago de Compostela



Investigação

2011-...: Investigadora Auxiliar, Universidade de Aveiro


2011: Investigadora, Institut Catalá d’Investigación Química (ICIQ)


2006-2010: Investigadora Auxiliar (programa IPP), Universidade de A Coruña


2004-2005: Investigadora Postdoctoral, Universidade de Oxford


2003: Investigadora Contratada, Universidade de Santiago de Compostela.




Interesses científicos
  • Química Organometalica: Novas reações mediadas por metais em química de carboidratos
  • Catálise asimétrica: Síntese de agentes de estereodiferenciação baseado em carboidratos.
  • Química de produtos naturais: Síntese de C-glycosidos
  • Foldameros: Síntese de aminoacidos hidroxilados e peptidomiméticos.


Artigos do SCI


R. G. Soengas, H. Rodríguez-Solla, A. Díaz-Pardo, R. Acúrcio, C. Concellón, V. del Amo, A. M. S. Silva, General Preparation of (E)-1-Substituted-1,3-dienes under Mild Conditions, Eur. J. Org. Chem., 2015, in press.

A. Estévez, R. G. Soengas, P. Thomas, M. Alegre, R. Balo, J. C. Estévez, R. J. Estévez, Stereocontrolled transformation of nitrohexofuranoses into cyclopentylamines via 2-oxabicyclo[2.2.1]heptanes. Part 6: synthesis and incorporation into peptides of the first reported 2,3-dihydroxycyclopentanecarboxylic acid, Tetrahedron: Asymmetry, 583-590, 2014.


R. Acúrcio, R. G. Soengas, A. M. S. Silva, Indium-Mediated Debromination of gem-Bromonitroalkanes under Mild Conditions in Aqueous Media, Synlett, 1561-1564, 2014.


R. Acúrcio, R.G. Soengas, A. M. S. Silva, Stereoselective Synthesis of Orthogonally Protected 1,2-Diaminoinositols from D-Mannose, Synlett, 2217-2220, 2014.


R. G. Soengas, R. Acúrcio, A. M. S. Silva, Recent Developments in The Chemistry of gem-Halonitro Compounds, Eur. J. Org. Chem., 6339-6359, 2014.


R.G. Soengas, R. Acúrcio, A. M. S. Silva, Preparation of indium nitronates and their Henry reactions, Org. Biomol. Chem., 12, 8593-8597, 2014.


H. Rodríguez-Solla, C. Concellón, N. Alvaredo, R. Llavona, S. García-Granda, R. M. Díaz, R. G. Soengas, Stereoselective Synthesis of Carbohydrate-Derived N-Sulfonyl Aziridines, Synlett 2013, 181-184.


H. Rodríguez-Solla, C. Concellón, V. del Amo, A. Díaz-Pardo, E. G. Blanco, S. García-Granda, M. R. Díaz, R. Llavona, R. G. Soengas, Synthesis of Highly Functionalized Enantiopure Halocyclopropanes Derived from Carbohydrates, Eur. J. Org. Chem. 2013, 4953-4961.


R. G. Soengas, A. M. Estévez, Applications of Barbier Type Reactions in Carbohydrate Chemistry, Curr. Org. Synth. 2013, 10, 183-209.


R. G. Soengas, A. M. S. Silva, Domino Reaction of Iodoglycosides: Synthesis of Carbohydrate Based Nitroalkenes, Eur. J. Org. Chem. 2013, 5022-5027.


R. G. Soengas, A. M. S. Silva, One-pot synthesis of vicinal aminoalkanols from sugar aldehydes, Tetrahedron 2013, 69, 3425-3431.


R. G. Soengas, A. M. S. Silva, Preparation of sugar-derived 1,2-diamines via indium-catalyzed aza-Henry-type reaction: application to the synthesis of 6-amino-1,6-dideoxynojirimycin, Tetrahedron Lett. 2013, 54, 2156-2159.


R.G. Soengas, A.M.S. Silva, One-Pot Three-Component Barbier-Type Reaction for the Synthesis of beta-Nitroamines, Synlett, 2013, 24, 1949 – 1952.


R.G. Soengas, H. Rodríguez-Solla, A.M.S.  Silva, R. Llavona, R, F.A. Almeida Paz, Synthesis of Enantiopure 2-C-Glycosyl-3-nitrochromenes, J. Org. Chem., 2013, 78, 12831 – 12836.


H. Rodríguez-Solla, C. Concellón, N. Alvaredo, R. G. Soengas, The use of samarium or sodium iodide salts as an alternative for the aza-Henry reaction, Tetrahedron, 2012, 68, 1736-1744.


H. Rodríguez-Solla, N. Alvaredo, Raquel G. Soengas, Synthesis of Sugar-derived 2-Nitroalkanols via Henry Reaction Promoted by Samarium Diiodide or Indium, Synlett, 2012, 2083-2086.


M. I. Simone, R. G. Soengas, S. Jenkinson, R. J. Nash, G. W. J. Fleet, Synthesis of piperidines with a branched carbon at C-2 from branched sugar lactones with a carbon substituent at C-2: three branched iminosugars [(3S,4R,5S)-3-(hydroxymethyl)piperidine-3,4,5-triol, (3R,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol and (3S,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol] and a branched trihydroxynipecotic acid [(3R,4R,5R)-3,4,5-trihydroxypiperidine-3-carboxylic acid], Tetrahedron: Asymm. 2012, 23, 401-408.


R. G. Soengas , A. M. S. Silva, Indium-Catalyzed Henry-Type Reaction of Aldehydes with Bromonitroalkanes. Synlett 2012, 873-875.


R. G. Soengas, A. M. Estévez, Indium-mediated allylation and Reformatsky reaction on glyoxylic oximes under ultrasound irradiation. Ultrasonics Sonochem. 2012, 19, 916-920.


R. G. Soengas, A. M. Estévez, Indium-mediated reaction of nitroethane and aldehydes: characterization of the nucleophilic organoindium species, Tetrahedron Lett. 2012, 53, 570-574.


R. G. Soengas, A. M. Estévez, J. C. Estévez, R. J. Estévez, Preparation of sugar-derived ?,?’-dihydroxy ?,?-disubstituted amino acids, Tetrahedron: Asymm. 2012, 23, 1238-1242.


R. G. Soengas, M. Fontanella, J. I. Santos, G. W. J. Fleet, J. Jiménez-Barbero, Synthesis and Conformational Analysis of Heterogeneous Cyclic Oligomers of 6-Amino-6-deoxygalactonic Acid and Phenylalanine, Eur. J. Org. Chem. 2012, 5701-5712.


R. G. Soengas, M. I. Simone, S. Hunter, R. J. Nash, E. L. Evinson, G. W. J. Fleet, Hydroxymethyl-Branched Piperidines from Hydroxymethyl-Branched Lactones: Synthesis and Biological Evaluation of 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-mannitol, 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-L-gulitol and 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-talitol, Eur. J. Org. Chem. 2012, 2394–2402.


R. G. Soengas, S. Silva, A. M. Estévez, J. C. Estévez, R. J. Estévez, H. Rodríguez Solla, Indium-mediated aza-Henry reaction of imines: a novel access to 2-nitroamines. Eur. J. Org. Chem. 2012, 4339-4346.


R. G. Soengas, Carbohydrate Mimetics as Potential Drug Candidates, Mini-rev. Med. Chem. 2012, 12, 1433-1433.


R. G. Soengas, S. Silva, Spirocyclic nucleosides in medicinal chemistry: an overview, Mini-rev. Med. Chem. 2012, 12, 1485-1496.


E. Iglesias, C. Jiménez, J. Rodríguez, R. G. Soengas, Physicochemical characterization of vanchrobactin, Metallomics 2011, 521-528.


H. Rodríguez-Solla, E. G. Blanco, J. I. Sarmiento, P. Díaz, R. G. Soengas, Chromium-Mediated Stereoselective Synthesis of Carbohydrate Derived (E)-???-Unsaturated Esters or Amides, J. Org. Chem. 2011, 76, 5461-5465.


R. G. Soengas, Y. Segade, C. Jiménez, J. Rodríguez, Highly diastereoselective indium-mediated synthesis of ?-lactam carbohydrates from imines, Tetrahedron 2011, 2617-2622.


A. M. Estévez, R. G. Soengas, J. Otero, J. C. Estévez, R. J. Estévez, Studies on the transformation of nitrosugars into iminosugars III: synthesis of (2R,3R,4R,5R,6R)-2-(hydroxymethyl)azepane-3,4,5,6-tetraol  and (2R,3R,4R,5R,6S)-2-(hydroxymethyl)azepane-3,4,5,6-tetraol, Tetrahedron: Asymm. 2010, 20, 21-26.


A. M. Estévez, R. G. Soengas, R. Tato, P. Thomas, J. C. Estévez, R. J. Estévez, Studies on the stereocontrolled transformation of nitrohexofuranoses into 2-oxabicyclo[2.2.1]heptanes. V: synthesis of enantiopure methyl (1R,2R,4S)-2-amino-4-hydroxycyclopentanecarboxylate, Tetrahedron: Asymm. 2010, 20, 116-120.


R. G. Soengas, A straightforward route to novel ?,?-disubstituted tetrahydrofuran ?-amino acids and spirodiketopiperazines from sugar lactones, Synlett 2010, 2549-2552.


R. G. Soengas, A. M. Estévez, Indium-mediated reaction of 1-bromo-1-nitroalkanes with aldehydes: a novel access to 2-nitroalkan-1-ols, Eur. J. Org. Chem. 2010, 5190- 5196.


R. G. Soengas, A. M. Estévez. Convenient procedure for the indium-mediated hydroxymethylation of active bromocompounds: transformation of ketones into ?-hydroxymethyl nitroalkanes, Synlett 2010, 2625-2627.


R. G. Soengas, Indium-mediated Reformatsky reaction on lactones: preparation of 2,2-dimethyl-3-ulosonic acids,Tetrahedron Lett. 2010 19, 105-108.


R. G. Soengas, J. C. Estévez, R. J. Estévez, An overview on the synthesis of furanoid and pyranoid sugar ?- and ?-amino acids and related aminocycloalkanecarboxylic acids from carbohydrates, Compt. Rend. Chimie 2010, 14, 313-326.


R. G. Soengas, Studies on the indium-mediated Reformatsky reaction on lactones: synthesis of 2-deoxy-2-substituted-3-ulosonic acids, Tetrahedron: Asymm. 2010, 20, 2249-2253.


última atualização a 07-04-2015
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