Pedro Miguel Dimas Neves Domingues

  Telefone: 234370700
  Extensão: 23511 E-mail: p.domingues@ua.pt
  Categoria: Professor Auxiliar
  Departamento: Química  Gabinete: 15.1.25
  Grupo de investigação: Espectrometria de Massa
  Pesquisa no ISI web of knowledge: Domingues P
  Saber mais em: Google scholar
  



Formação académica

2014 - Agregação em Bioquímica.


2000 - Doutoramento em Química, especialidade de Espectrometria de Massa tendo defendido a dissertação "Aplicações da Espectrometria de Massa ao Estudo do Stress Oxidativo em Fosfolípidos".


1996 - Provas de Aptidão Pedagógica e Capacidade Científica na Universidade de Aveiro.


1990 - Licenciatura em Ciências Farmacêuticas, Ramo de Farmácia de Oficina e Hospitalar, pela Faculdade de Farmácia da Universidade de Coimbra.



Percurso profissional

2014 - Professor auxiliar com Agregação do Departamento de Química da Universidade de Aveiro, Membro do grupo de espectrometria de massa, QOPNA.


2000 - Professor Auxiliar no Departamento de Química da Universidade de Aveiro.


1996 - Assistente no Departamento de Química da Universidade de Aveiro.


1992 - Assistente Estagiário no Departamento de Química da Universidade de Aveiro.



Interesses científicos

Pedro Domingues tem trabalhado em espectrometria de massa desde 1996. Os seus interesses científicos estão relacionados com o desenvolvimento de aplicações em espectrometria de massa que permitam o estudo do stress oxidativo in vivo. As principais linhas de investigação têm-se desenvolvido na deteção e caracterização de radicais livres usando a espectrometria de massa e no estudo do efeito do stress oxidativo em lípidos, péptidos e proteínas.



Grupo de investigação

Investigadores de pós-doutoramento: Doutora Sofia de Morais Correia Pereira Guedes.


Estudantes de Doutoramento:


Cláudia de Jesus Fernandes Covas "Unravel the biosynthesis and bioactivity of Bacteroidetes lanthipeptides" (SFRH/BD/98446/2013);


Ana Mafalda R. Almeida “IgY Technology: A Purification Platform using Ionic-Liquid-Based Aqueous Biphasic Systems (IgYPurTech)”;


Ana Rita Parente Figueiredo “Microalgae as sustainable source of lipids for nutrition and phytochemicals" (bolsa de Doutoramento no Programa Doutoral em Química Sustentável);

JF Montero Bullón “MS analytical strategies for identifying nitrooxidative modifications in phospholipids in vivo” (H2020 MSCA-ITN-ETN MASSTRPLAN);

Simone Colombo "MS analytical strategies for identifying aminophospholipid oxidation and their correlation with immunity" (H2020 MSCA-ITN-ETN MASSTRPLAN).


Artigos do SCI


(2016-2018)


1. Łuczaj, W.; Moniuszko-Malinowska, A.; Domingues, P.; Domingues, M.R.; Gindzienska-Sieskiewicz, E.; Skrzydlewska, E.; Plasma lipidomic profile signature of rheumatoid arthritis versus Lyme arthritis patients, in Archives of Biochemistry and Biophysics, 2018, VL.654, pp.105-114.


2. Maciel, E.; Lillebø, A.; Domingues, P.; da Costa, E.; Calado, R.; Domingues, M.R.M.; Polar lipidome profiling of Salicornia ramosissima and Halimione portulacoides and the relevance of lipidomics for the valorization of halophytes, in Phytochemistry, 2018, VL.153, pp.94-101.


3. Colombo, Simone; Melo, Tania; Martinez-Lopez, Marta; Carrasco, M. Jesus; Domingues, M. Rosario; Perez-Sala, Dolores; Domingues, Pedro; Phospholipidome of endothelial cells shows a different adaptation response upon oxidative, glycative and lipoxidative stress; in Scientific reports, 2018, VL.8, AR: 12365. [Open Access]


4. Laranjeira, P.; Duque, M.; Vojtek, M.; Inácio, M.J.; Silva, I.; Mamede, A.C.; Laranjo, M.; Pedreiro, S.; Carvalho, M.J.; Moura, P.; Abrantes, A.M.; Maia, C.J.; Domingues, P.; Domingues, R.; Martinho, A.; Botelho, M.F.; Trindade, H.; Paiva, A.; Amniotic membrane extract differentially regulates human peripheral blood T cell subsets, monocyte subpopulations and myeloid dendritic cells, in Cell and Tissue Research, 2018, VL.373, pp.459-476.


5. Alves, E.; Domingues, M.R.M.; Domingues, P.; Polar Lipids from Olives and Olive Oil: A Review on Their Identification, Significance and Potential Biotechnological Applications, in Foods, 2018, VL.7, AR: 109.


6. Gegotek, A.; Domingues, P.; Wronski, A.; Wojcik, P.; Skrzydlewska, E.; Proteomic plasma profile of psoriatic patients, in Journal of Pharmaceutical and Biomedical Analysis, 2018, VL.155, pp.185-193.


7. Gegotek, A.; Domingues, P.; Skrzydlewska, E.; Proteins involved in the antioxidant and inflammatory response in rutin-treated human skin fibroblasts exposed to UVA or UVB irradiation, in Journal of Dermatological Science, 2018, VL.90, pp.241-252.


8. Alves, E.; Rey, F.; da Costa, E.; Moreira, A.S.P.; Pato, L.; Pato, L.; Domingues, M.D.M.; Domingues, P.; Olive (Olea europaea L. cv. Galega vulgar) Seed Oil: A First Insight into the Major Lipid Composition of a Promising Agro-Industrial By-Product at Two Ripeness Stages, in European Journal of Lipid Science and Technology, 2018, VL.120, AR: 1700381.


9. Silva, E.M.P.; Varandas, P.A.M.M.; Melo, T.; Barros, C.; Alencastre, I.S.; Barreiros, L.; Domingues, P.; Lamghari, M; Domingues, M.R.M.; Segundo, M.A.; Gas-phase structural characterization of neuropeptides Y Y1 receptor antagonists using mass spectrometry: Orbitrap vs triple quadrupole, in Journal of Pharmaceutical and Biomedical Analysis, 2018, VL.151, pp.227-234.


10. Colombo, S.; Coliva, G.; Kraj, A.; Chervet, J.P.; Fedorova, M.; Domingues, P.; Domingues, M.R.; Electrochemical oxidation of phosphatidylethanolamines studied by mass spectrometry, in Journal of Mass Spectrometry, 2018, VL.53, pp.223-233.


11. Dias, A.S.; Castro, A.L.; Melo, P.; Tarelho, S.; Domingue, P.; Franco, J.M.; A fast method for GHB-GLUC quantitation in whole blood by GC-MS/MS (TQD) for forensic purposes, in Journal of Pharmaceutical and Biomedical Analysis, 2018, VL.150, pp.107-111.


12. Araujo, Ana Rita D.; Melo, Tania; Maciel, Elisabete A.; Pereira, Clara; Morais, Catarina M.; Santinha, Deolinda R.; Tavares, Joana F.; Oliveira, Helena; Jurado, Amalia S.; Costa, Vitor; Domingues, Pedro; Domingues, Maria Rosario M.; Santos, Manuel A.S.; Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast, in PloS one, 2018, VL.13, AR: e0202402. [Open Access]


13. da Costa, E.; Azevedo, V.; Melo, T.; Rego, A.M.; Evtuguin, D.V.; Domingues, P.; Calado, R.; Pereira, R.; Abreu, M.H.; Domingues, M.R.; High-Resolution Lipidomics of the Early Life Stages of the Red Seaweed Porphyra dioica, in Molecules, 2018, VL.23, AR: 187.


14. Melo, T.; Marques, S.S.; Ferreira, I.; Cruz, M.T.; Domingues, P.; Segundo, M.A.; Domingues, M.R.M.; New Insights into the Anti-Inflammatory and Antioxidant Properties of Nitrated Phospholipids, in Lipids, 2018, VL.53, pp.117-131.


15. Rey, F.; Domingues, M.R.M.; Domingues, P.; Rosa, R.; Orgaz, M.D.M.; Queiroga, H.; Calado, R.; Effect of Maternal Size, Reproductive Season and Interannual Variability in Offspring Provisioning of Carcinus maenas in a Coastal Lagoon, in Estuaries and Coasts, 2017, VL.40, pp.1732-1743.


16. Rey, Felisa; da Costa, Elisabete; Campos, Ana M.; Cartaxana, Paulo; Maciel, Elisabete; Domingues, Pedro; Domingues, M. Rosario M.; Calado, Ricardo; Cruz, Sonia; Kleptoplasty does not promote major shifts in the lipidome of macroalgal chloroplasts sequestered by the sacoglossan sea slug Elysia viridis, in Scientific Reports, 2017, VL.7, AR: 11502.


17. Moreira, Ana S.P.; Nunes, Fernando M.; Simoes, Cristiana; Maciel, Elisabete; Domingues, Pedro; Domingues, M. Rosario M.; Coimbra, Manuel A.; Data on coffee composition and mass spectrometry analysis of mixtures of coffee related carbohydrates, phenolic compounds and peptides, in Data in brief, 2017, VL.13, pp.145-161. [Open Access]


18. Moreira, A.S.P.; Nunes, F.M.; Simoes, C.; Maciel, E.; Domingues, P.; Domingues, M.R.M.; Coimbra, M.A.; Transglycosylation reactions, a main mechanism of phenolics incorporation in coffee melanoidins: Inhibition by Maillard reaction, in Food Chemistry, 2017, VL.227, pp.422-431.


19. Domingues, Patricia M.; Almeida, Adelaide; Leal, Luisa Serafim; Gomes, Newton C.M.; Cunha, Angela; Bacterial production of biosurfactants under microaerobic and anaerobic conditions, in Reviews in Environmental Science and Bio-Technology, 2017, VL.16, pp.239-272.


20. Melo, Tania; Domingues, Pedro; Ribeiro-Rodrigues, Teresa M.; Girao, Henrique; Segundo, Marcela A.; Domingues, M. Rosario M.; Characterization of phospholipid nitroxidation by LC-MS in biomimetic models and in,H9c2 Myoblast using a lipidomic approach, in FREE RADICAL BIOLOGY AND MEDICINE, 2017, VL.106, pp.219-227.


21. Kuznetsova, A.; Domingues, P.M.; Silva, T.; Almeida, A.; Zheludkevich, M.L.; Tedim, J.; Ferreira, M.G.S.; Cunha, A.; Antimicrobial activity of 2-mercaptobenzothiazole released from environmentally friendly nanostructured layered double hydroxides, in Journal of Applied Microbiology, 2017, VL.122, pp.1207-1218.


22. Maciel, E.; Felgueiras, J.; Silva, E.M.P.; Ricardo, F.; Moreira, A.S.P.; Melo, T.; Campos, A.; Fardilha, M.; Domingues, P.; Domingues, M.R.; Lipid remodelling in human melanoma cells in response to UVA exposure, in Photochemical & Photobiological Sciences, 2017, VL.16, pp.744-752.


23. Capela, E.V.; Quental, M.V.; Domingues, P.; Coutinho, J.A.P.; Freire, M.G.; Effective separation of aromatic and aliphatic amino acid mixtures using ionic-liquid-based aqueous biphasic systems, in Green Chemistry, 2017, VL.19, pp.1850-1854.


24. da Costa, Elisabete; Melo, Tania; Moreira, Ana S.P.; Bernardo, Carina; Helguero, Luisa; Ferreira, Isabel; Cruz, Maria Teresa; Rego, Andreia M.; Domingues, Pedro; Calado, Ricardo; Abreu, Maria H.; Domingues, Maria Rosario; Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity, in Marine drugs, 2017, VL.15, AR: 62.


25. de Lima, F.B.; Feix, C.; Osoio, N.; Alves, A.; Vitorino, R.; Domingues, P.; Ribeiro, R.T.D.; Esteves, A.C.; Trichoderma harzianum T1A constitutively secretes proteins involved in the biological control of Guignardia citricarpa, in Biological Control, 2017, VL.106, pp.99-109.


26. Guedes, S.; Neves, B.; Vitorino, R.; Domingues, R.; Cruz, M.T.; Domingues, P.; Contact dermatitis: in pursuit of sensitizer's molecular targets through proteomics, in Archives of Toxicology, 2017, VL.91, pp.811-825.


27. Auczaj, W.; Domingues, P.; Domingues, M.R.; Pancewicz, S.; Skrzydlewska, E.; Phospholipidomic Analysis Reveals Changes in Sphingomyelin and Lysophosphatidylcholine Profiles in Plasma from Patients with Neuroborreliosis, in Lipids, 2017, VL.52, pp.93-98.


28. Martins, J.D., Maciel, E.A., Silva, A., Ferreira, I., Ricardo, F., Domingues, P., Neves, B.M., Domingues, M.R.M., Cruz, M.T.; Phospholipidomic Profile Variation on THP-1 Cells Exposed to Skin or Respiratory Sensitizers and Respiratory Irritant, in Journal of Cellular Physiology, 2016, VL.231, pp.2639-2651.


29. Couto, D.; Melo, T.; Maciel, E.; Campos, A.; Alves, E.; Guedes, S.; Domingues, M.R.; Domingues, P.; New insights on non-enzymatic oxidation of ganglioside GM1 using mass spectrometry, in Journal of the American Society for Mass Spectrometry, 2016, VL.27, pp.1965-1978.


30. Alves, E.; Melo, T.; Rey, F.; Moreira, A.S.P.; Domingues, P.; Domingues, M.R.; Polar lipid profiling of olive oils as a useful tool in helping to decipher their unique fingerprint, in LWT-Food Science and Technology, 2016, VL.74, pp.371-377.


31. Campos, A.M., Ricardo, F., Alves, E., Reis, A., Couto, D., Domingues, P., Domingues, M.R.M.; Lipidomic investigation of eggs' yolk: Changes in lipid profile of eggs from different conditions, in Food Research International, 2016, VL.89, pp.177-185.


32. Coelho, Francisco J.R.C.; Louvado, Antonio; Domingues, Patricia M.; Cleary, Daniel F.R.; Ferreira, Marina; Almeida, Adelaide; Cunha, Marina R.; Cunha, Angela; Gomes, Newton C.M.; Integrated analysis of bacterial and microeukaryotic communities from differentially active mud volcanoes in the Gulf of Cadiz, in Scientific Reports, 2016, VL.6, AR: 35272.


33. Sousa, B., Melo, T., Campos, A., Moreira, A.S.P., Maciel, E., Domingues, P., Carvalho, R.P., Rodrigues, T.R., Girao, H., Domingues, M.R.M.; Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia, in Journal of Cellular Physiology, 2016, VL.231, pp.2266-2274.


34. Simoes, J., Moreira, A.S.P., da Costa, E., Evtyugin, D., Domingues, P., Nunes, F.M., Coimbra, M.A.,  Domingues, R.M.; Oxidation of amylose and amylopectin by hydroxyl radicals assessed by electrospray ionisation mass spectrometry, in Carbohydrate Polymers, 2016, VL.148, pp.290-299.


35. Felix, C., Duarte, A.S., Vitorino, R., Guerreiro, A.C.L., Domingues, P., Correia, A.C.M., Alves, A., Esteves, A.C.; Temperature Modulates the Secretome of the Phytopathogenic Fungus Lasiodiplodia theobromae, in Frontiers in Plant Science, 2016, VL.7, AR: 1096.


36. de Lima, F.B., Felix, C., Osorio, N., Alves, A., Vitorino, R., Domingues, P., Correia, A., Ribeiro, R.T.D., Esteves, A.C.; Secretome analysis of Trichoderma atroviride T17 biocontrol of Guignardia citricarpa, in Biological Control, 2016, VL.99, pp.38-46.


37. Campos, A.M., Maciel, E., Moreira, A.S.P., Sousa, B., Melo, T., Domingues, P., Curado, L., Antunes, B., Domingues, M.R.M., Santos, F.; Lipidomics of Mesenchymal Stromal Cells: Understanding the Adaptation of Phospholipid Profile in Response to Pro-Inflammatory Cytokines, in Journal of Cellular Physiology, 2016, VL.231, pp.1024-1032.


38. Rey, F., Moreira, A.S.P., Ricardo, F., Coimbra, M.A., Domingues, M.R.M., Domingues, P., Rosa, R., Queiroga, H., Calado, R.; Fatty Acids of Densely Packed Embryos of Carcinus maenas Reveal Homogeneous Maternal Provisioning and No Within-Brood Variation at Hatching, in Biological Bulletin, 2016, VL.230, pp.120-129.


39. Moreira, A.S.P., Simoes, J., Nunes, F.M., Evtuguin, D.V., Domingues, P., Coimbra, M.A., Domingues, M.R.M.; Nonenzymatic Transglycosylation Reactions Induced by Roasting: New Insights from Models Mimicking Coffee Bean Regions with Distinct Polysaccharide Composition, in Journal of Agricultural and Food Chemistry, 2016, VL.64, pp.1831-1840.


40. Maciel, E., Leal, M.C., Lillebø, A.I, Domingues, P., Domingues, M.R., Calado, R.; Bioprospecting of marine macrophytes using MS-based lipidomics as a new approach, in Marine Drugs, 2016, VL.14, AR:49.


41. Melo, T., Domingues, P., Ferreira, R., Milic, I., Fedorova, M., Santos, S.M., Segundo, M.A., Domingues, MRM; Recent Advances on Mass Spectrometry Analysis of Nitrated Phospholipids, in Analytical Chemistry, 2016, VL.88, pp.2622-2629.




última atualização a 12-09-2018
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