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margarida fardilha
biographical description

Margarida Fardilha did a degree in Biochemistry in 1996 at the University of Porto, a PhD in Biology (2004) at the University of Aveiro, and is Invited Assistant Professor at the Aveiro Health Sciences Department.

e-mail: mfardilha@ua.pt 


research interests
Margarida is studying the role of the Phosphoprotein Phosphatase 1 (PPP1) in male-related disorders. PPP1 is one of the most conserved phosphatases and it is involved in several processes. The specificity and activity of PPP1 depends on its binding partners, known as PPP1-interacting proteins (PIPs). Margarida is particularly interested in understanding the molecular mechanisms associated with male infertility and prostate cancer and identify molecular targets suitable for diagnosis, prognosis and therapy. Hence, she wishes to identify and characterize 1) PPP1 and PIPs interactomes in male reproductive-related tissues, using the Yeast Two-Hybrid system and conventional biochemical methods to validate protein interactions; 2) protein complexes that may be used as therapy targets or prognostic/diagnostic tools; 3) develop tools to target protein complexes. Her ultimate goal is to translate basic research knowledge to clinical applications.

selected publications
Silva JV, Yoon S, Domingues S, Guimarães S, Goltsev AV, da Cruz E Silva E, Mendes J, da Cruz E Silva O, Fardilha M. Amyloid precursor protein interaction network in human testis: sentinel proteins for male reproduction. BMC Bioinformatics. 2015 Jan 16; 16(1):12.

 2. Silva JV, Korrodi-Gregório L, Luers G, Cardoso MJ, Patrício A, Maia N, da Cruz E Silva EF, Fardilha M. Characterisation of several ankyrin repeat protein variant 2, a phosphoprotein phosphatase 1-interacting protein, in testis and spermatozoa. Reprod Fertil Dev. 2015 Jan 7. doi: 10.1071/RD14303.

3. Korrodi-Gregório L, Esteves SL, and Fardilha M. Protein phosphatase 1 catalytic isoforms: specificity towards interacting proteins. Transl Res. 2014 Nov; 164(5):366-91. doi: 10.1016/j.trsl.2014.07.001.

4. Korrodi-Gregório L, Silva JV, Santos-Sousa L, Freitas, MJ, Felgueiras J and Fardilha M. TGFβ cascade regulation by PPP1 and its interactors - impact on prostate cancer development and therapy. Journal of Cellular and Molecular Medicine Apr; 18(4):555-67. DOI: 10.1111/jcmm.12266.

5. Fardilha M, Esteves SL, Korrodi-Gregório L, Vintém AP, Domingues SC, Rebelo S, Morrice N, Cohen PTW, Da Cruz E Silva, OA, Da Cruz E Silva EF. Identification of the Human Testis Protein Phosphatase 1 Interactome. Biochem Pharmacol. 2011 Nov 15; 82(10):1403-15. doi: 10.1016/j.bcp.2011.02.018.

última atualização a 29-04-2016
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