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daniela


sandra rebelo
biographical description

Sandra Rebelo has a degree (2000), a masters in Molecular Microbiology (2003), a PhD in Biochemistry (2008) and a postdoc in Biology from the University of Aveiro. She is invited assistant professor at the Aveiro Health Sciences Department.

e-mail: srebelo@ua.pt

bibliometry
https://scholar.google.pt/citations?user=MkmtZWIAAAAJ&hl=pt-PT

research interests
Sandra is studying LAP1:PP1 phosphocomplex that she identified (Santos et al, 2013). LAP1 is a nuclear envelope protein whose function is poorly understood, but is known to interact with torsinA - a protein central to the neurological disorder DYT1 dystonia - and also with the nuclear protein emerin which is associated with muscular dystrophies. LAP1B and LAP1C are phosphorylated at five residues (Santos et al, 2014) and Sandra is investigating the impact of LAP1 phosphorylation on DYT1 dystonia and muscular dystrophy. LAP1 is also crucial for the maintenance of the nuclear envelope (NE) and cell cycle progression (Santos et al, 2015). Sandra I also interested on the identification of the proteins that interact with LAP1.

selected publications
1.
Santos, M., Rebelo, S., Van Kleeff, P., Kim, C. E., Dauer, T. W, Fardilha, M., da Cruz e Silva, O. A. B and Edgar da Cruz e Silva, E. F. (2013). The nuclear envelope protein, LAP1B, is a novel Protein Phosphatase 1 substrate. PLoS One 8:e76788.

 2. Rebelo, S., Domingues, S. C. T. S., Santos, M., Fardilha, M., Esteves, S. L. C., Vieira, S. I., Vintém, A. P. B., Wu, W., da Cruz e Silva, E. F. and da Cruz e Silva, O. A. B. (2013). Identification of a novel Complex AβPP:Fe65:PP1 that regulates APP Thr668 phosphorylation levels. Journal of Alzheimer’s Disease 35: 761-775.

3. Santos, M., Domingues, S. C., Costa, P., Thorsten, M., Galozzi, S., Marcus, K., da Cruz e Silva E. F., Da cruz e Silva, O. A. B. and Rebelo, S. (2014). Identification of a novel human LAP1 isoform that is regulated by protein phosphorylation. PLoS One 9:e113732.

4. Santos, M., Costa, P., Martins, F., da Cruz e Silva E. F., Da cruz e Silva, O. A. B. and Rebelo, S. (2015). A novel role of LAP1 in centrosome positioning near the nuclear envelope during the cell cycle. Mol Cell Biochem 399:143-53.

5. Santos M., Rebelo S., Dauer W. T., da Cruz e Silva E. F. and da Cruz e Silva O. A. B. (2015). DYT1 dystonia-associated mutant affects cytoskeleton dynamics. Microscopy and Microanalysis (in press).

última atualização a 29-04-2016
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