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odete cruz e silva
biographical description

Odete da Cruz e Silva is Principal Investigator of the Neuroscience and Cell Signalling Group. She trained with Sir Philip Cohen and Prof. Paul Greengard (Rockefeller University). Is presently Review Editor for Frontiers in Aging Neuroscience and Associate Editor in the Journal of Alzheimer’s Disease and has participated in 4 European projects (Biomark-APD, cNeupro, APOPIS and DIADEM.

e-mail: odetecs@ua.pt


research interests
Research focuses on the molecular basis of neuropathologies such as Alzheimer’s Disease, Parkinson’s disease and Torsion Dystonia. Particular effort has focused on protein phosphorylation dependent events, proteolytic protein processing and protein aggregation mechanisms, particularly with respect to Abeta, Tau, and other proteins involved in neuropahtologies. A Systems Biology approach has been employed to unravel several protein interactomes, and several novel protein binding partners were identified, that revealed novel functional multimeric complexes. Many of these complexes contain protein phosphatase 1 and are regulated by the latter (i.e. APP:Fe65:PP1 and torsinA:LAP1:PP1). Of note, the group described a curious distribution of APP (Alzheimer’s precursor protein) in sperm. This led to studying the neuron and the sperm in parallel from a molecular and cell biology perspective. Hence there is a strong comparative research line between Cellular and Synaptic signalling. Other areas of research include, Stem Cell based prognostics and therapeutics and Neuronal Regeneration. On the Translational Clinical research front, efforts have focused on Biomarker Discovery. To this end the group is responsible for the Av-cohort; a group of 600 volunteers in the Aveiro region, participating in cognitive tests and the Biomarker discovery project. The group also offers to the community the CSF-based neurochemical diagnosis of dementia. The approach used is highly multidisciplinary, employing molecular and cell biology approaches, confocal microcopy, Multi Electrode Array Systems, biophysical and bioinformatics procedures.

selected publications
Batista F, Henriques AG, Silva A, Wiltfang J and da Cruz e Silva OAB (2014). Flavonoids as therapeutic compounds targeting key proteins involved in Alzheimer ́s disease. ACS Chemical Neuroscience, 5 (2) 83 – 92. doi: 10.1021/cn400213r.

 2. da Cruz e Silva OAB, Henriques AG, Domingues SCTS and da Cruz e Silva EF (2010). Wnt Signalling is a Relevant Pathway Contributing to Amyloid Beta- Peptide-Mediated Neuropathology in Alzheimer's Disease. Central Nervous System & Neurological Disorders-Drug Targets. 9, 720-6.

3. Rebelo S, Vieira SI, Esselmann H, Wiltfang J, da Cruz e Silva EF and da Cruz e Silva OAB (2007). Tyr(687) dependent APP endocytosis and Abeta production. J. Mol. Neuroscience 32, 1-8. doi: 10.1007/s12031-007-0001-z.

4. Henriques AG, Vieira SI, da Cruz e Silva EF and da Cruz e Silva OAB (2009). Abeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures. J. Mol. Neuroscience 39, 248-255. doi:10.1007/s12031-009-9192-9

5. Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah J, Lane R, Small SA, Gandy S, da Cruz E Silva EF, da Cruz E Silva OA (2010) Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Molecular Neurodegeneration. 5:40, 1-21.

última atualização a 29-04-2016
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