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evelina gatti

philippe pierre
biographical description

Philippe PIERRE is an international leader in dendritic cell immunobiology. After a Ph. D. in Cell Biology at EMBL in Heidelberg (Germany) and The University of Geneva (Switzerland), he spent 5 years at the Yale University School of Medicine (New-Haven , CT, USA), as a post-doctoral fellow in Immunobiology. He is best known for the discovery of multiple mechanisms controlling antigen presentation and DC activation after microbial detection. Philippe Pierre has led a group at the Center of Immunology of Marseille-Luminy (www.ciml.univ-mrs.fr) and joined iBiMED in 2015.

e-mail: pierre@ciml.univ-mrs.fr   |


research interests
His work has been focused on the elucidation of MHC membrane traffic and antigen presentation in dendritic cells and the role of proteolysis and ubiquitin during this process. The group has pioneered the study of the aggregation of mistranslated products (DALIS) and the importance of mRNA translation during dendritic cells activation. The team has also characterized new molecules expressed in dendritic cell subtypes and their specific regulation mechanisms. Philippe Pierre’s group has pioneered a technique for the non-radioactive monitoring of protein synthesis, which has created a great interest in life science community and led to new findings in different field of life sciences. His current research interests include elucidation of MHC membrane traffic and antigen presentation, the role of proteolysis and ubiquitin during this process and control of translation in dendritic cells, as well as the fundamental changes occurring during pathogen detection.

selected publications
Terawaki S, Camosseto V, Prete F, Wenger T, Papadopoulos A, Rondeau C, Combes A, Rodriguez Rodrigues C, Vu Manh TP, Fallet M, English L, Santamaria R, Soares AR, Weil T, Hammad H, Desjardins M, Gorvel JP, Santos MA, Gatti E, Pierre P. (2015). RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4. J Cell Biol., 210, 1133. doi: 10.1083/jcb.201501059.

 2. Pierre P, Gatti E. (2013) Loss of translation: a stealth weapon against pathogens? Nat Immunol., 14, 1203. doi: 10.1038/ni.2759.

3. Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E. (2013) Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci., 16, 1299. doi: 10.1038/nn.3486.

4. Clavarino G, Cláudio N, Dalet A, Terawaki S, Couderc T, Chasson L, Ceppi M, Schmidt EK, Wenger T, Lecuit M, Gatti E, Pierre P. (2012) Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells. Proc Natl Acad Sci USA., 109, 3006. doi: 10.1073/pnas.1104491109.

5. Lelouard H, Gatti E, Cappello F, Gresser O, Camosseto V, Pierre P. (2002) Transient aggregation of ubiquitinated proteins during dendritic cell maturation. Nature, 417, 177.

última atualização a 30-11-2016
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